Optimization of Steam Distillation Process for Volatile Oils from Forsythia suspensa and Lonicera japonica according to the Concept of Quality by Design

In this study, the process of steam distillation to collect volatile oils from Forsythia suspensa (F. suspensa) and Lonicera japonica (L. japonica) was optimized according concept quality by design. First, liquid/material ratio, time, collection temperature were identified as critical parameters a review literature single-factor experiments. Then, Box–Behnken design used study quantitative relationship between three parameters, two raw material properties, yield oil. A mathematical model established with an R2 value exceeding 0.90. Furthermore, space oil calculated probability-based method. The results verification experiment showed that accurate reliable. total 16 chemical constituents in mixtures F. L. japonica. content β-pinene highest (54.75%), composition similar suspensa. when distilled together, main contribution combination not higher than